Abstract Central to homologous recombination (HR) is the assembly of Rad51 recombinase on single-strand DNA (ssDNA), Soft Toy forming the Rad51-ssDNA filament.How the Rad51 filament is efficiently established and sustained remains partially understood.Here, we find that the yeast ubiquitin ligase Bre1 and its human homolog RNF20, a tumor suppressor
Based on the data obtained by the UMITAKA-MARU (Tokyo Univ.of Fisheries, 1453) during the period from Dec.1961 to Feb.1962, the general oceanographic conditions are discussed in this paper.During this expedition the temperature, salinity, dissolved oxygen, PH, Phosphate-P and Silicate-Si are investigated at all stations.As a result the followings a
BackgroundThe heterogeneity of cancer makes it challenging to predict its response to immunotherapy, highlighting the need to find reliable biomarkers for assessment.The sophisticated role of cancer stemness in mediating resistance to immune checkpoint inhibitors (ICIs) is still inadequately comprehended.MethodsGenome-scale CRISPR screening of RNA